Metabolic Insights Profile (Organic Acids)

A Comprehensive Functional Assessment of Metabolic, Mitochondrial, and Microbiome Health

At KBMO Diagnostics, we believe in going beyond the surface to identify the root causes of chronic illness. Our Metabolic Insights Profile (Organic Acids) looks at 5 key groups—metabolic function, detoxification capacity, microbial health, neurotransmitter balance, and more—all through a simple urine sample.

The MIP is a diagnostic tool designed to empower practitioners and patients with actionable data leading to personalised treatment strategies. Powered by the latest research in sample preparation and LC/MS/MS technology this novel test is the cutting edge of Organic Acids. It is Next Generation Organic Acid Testing.

Seamless Testing.Powerful Results.

KBMO’s MIP is not just a lab test—it’s a diagnostic tool designed to empower practitioners and patients with actionable data. Backed by peer-to-peer support and educational resources, our comprehensive reports help inform personalized treatment strategies.

  • Microbial Metabolites
  • Detox Indicators
  • Metabolism and Mitochondrial Function
  • Nutrition Markers & Oxalates
  • Neurotransmitter Metabolism Markers

Microbial Metabolites

The gut is crucial for digestion, immune health, and brain function, often called the body’s second brain. It produces important molecules that affect various bodily processes.

However, an overgrowth of harmful bacteria can release toxins into the bloodstream, disrupting overall health and highlighting the need for a balanced gut microbiome.

Pathogenic bacteria can disrupt the balance of beneficial bacteria that play a crucial role in regulating various systems throughout the body. Additionally, molds such as Aspergillus and Penicillium can colonize the body, particularly in areas like the gut and nasal passages. These molds may release mycotoxins, which can have harmful effects on health.

Detoxification Indicators

Glutathione is a crucial antioxidant that plays a significant role in the body’s detoxification processes. It helps eliminate a wide range of harmful chemicals and toxins, supporting the liver in its efforts to cleanse the body. By neutralizing free radicals and facilitating the excretion of heavy metals and other pollutants, glutathione is vital for maintaining overall health and preventing cellular damage. Monitoring the glutathione cycle is essential for effectively evaluating the body’s detoxification process and understanding the extent of toxic exposure it encounters.

Metabolism and Mitochondrial Function

The mitochondria serve as the powerhouse of the cell, playing a crucial role in energy production. Maintaining the proper functioning of mitochondria is vital for overall health, as their efficiency directly impacts the body’s energy levels, metabolism, and overall well-being.

A range of health issues can contribute to the dysfunction of mitochondria, which are the energy-producing structures within our cells. Some of these issues include inadequate nutrition, where a lack of essential vitamins and minerals can impair mitochondrial function. Additionally, a high toxic burden from environmental pollutants, heavy metals, and other harmful substances can damage mitochondrial health.

Chronic illnesses, such as metabolic disorders or autoimmune diseases, may also negatively impact mitochondrial performance. Monitoring these markers can assist in identifying underlying issues and aid practitioners in developing personalized treatment plans.

Nutrition Markers

Analyzing levels of fatty acids and ketones in the body can provide valuable insights into imbalances that may be associated with various health conditions, including cardiovascular diseases and inflammatory disorders. By understanding these metabolic profiles, healthcare providers can create tailored dietary and supplementation strategies that focus on enhancing fatty acid levels. This personalized approach not only aims to restore balance but also helps to mitigate the potential long-term health impacts resulting from these imbalances.

Oxalates

Oxalates can be found in a wide range of foods, including berries, nutrient-rich vegetables like spinach and beets, and healthy nuts and seeds. It is also found in popular beverages, including tea, coffee, and rich chocolate. When oxalate levels in the body become too high, they can contribute to the formation of kidney stones and other significant health problems. Oxalate is a naturally occurring organic acid that the human body can synthesize on its own. As oxalate can bind with minerals, it is important to monitor oxalate intake to maintain good health and well-being.

Neurotransmitter Metabolism

Neurotransmitters are produced in various parts of the body, including the central nervous system (CNS), the peripheral nervous system (PNS), and other areas such as the renal system. The relationship between neurotransmitter levels in the central nervous system (CNS) and their excretion is still being studied, and definitive results are not yet available. One important factor to consider is that the enzymes found in the CNS rely on the same cofactors for their activity. This overlap in cofactors may influence both neurotransmitter synthesis and metabolism, possibly affecting how neurotransmitters are processed and eliminated from the body. Understanding these dynamics could provide deeper insights into the regulation of neurotransmitter levels and their effects on neurological health. Increased levels of precursors may indicate underlying issues. Additionally, The ratio of vanilmandelate to homovanillate may reflect low expression or activity of dopamine beta-hydroxylase or other enzymes in the metabolic pathway.

Providing patients with individual data that is actionable and easy to understand.

The KBMO MIP can help in identifying:

  • Microbiome Imbalances
  • Fungal Colonization
  • Malnutrition
  • Autoimmune Diseases
  • Metabolic Disorders
  • Detoxification Processes
  • PANS/PANDAS
  • Neurological Disorders
  • Memory Retention
  • Depression/Anxiety
  • Cardiovascular Disease
  • Oxidative Stress
  • Energy Production
  • and much more!

When you order a test from KBMO Molecular Diagnostics, you will receive the most sensitive and accurate results but also:

  • Peer-to-peer support
  • Easy-to-use sample collection system
  • Quickest turn-around times in the industry
  • HIPAA protected practitioner’s portal
  • Experienced sales executives
  • Educational resources
  • Scientist-developed and owned
  • Scientists with 60 years of combined experience

Metabolic Insights Profile Frequently Asked Questions (FAQs)

What is the MIP (Metabolic & Immune Profile) test?2026-08-27T17:30:03+01:00
The MIP test is a comprehensive urine-based organic acid analysis that assesses various biological markers related to gut health, detoxification, mitochondrial function, neurotransmitters, nutrition, and oxalate levels.
Can patients order a test directly from KBMO?2026-08-27T17:30:31+01:00
No. Patients need to go through a practitioner to order a test.  Please call our customer service to find a practitioner near you.
What sample is required for the test?2026-08-27T17:30:55+01:00
A urine sample of 5–7 mL is required.
Are there any special requirements for sample collection?2026-08-27T17:31:27+01:00
Yes. Refer to the provided collection instructions for dietary restrictions prior to sample collection.
How long does it take to get results?2026-08-27T17:31:50+01:00
The turnaround time (TAT) is 7–10 business days.
How are results delivered?2026-08-27T17:32:12+01:00
Results are made available through a HIPAA-protected provider’s portal.
What areas does the MIP test analyze?2026-08-27T17:32:49+01:00
Detox Indicators: Includes markers like glutathione that help assess toxin elimination.

Microbial Metabolites: Assesses byproducts of harmful bacterial or fungal overgrowth.

Mitochondrial Function: Evaluates energy production and cellular metabolism.

Neurotransmitter Metabolism: Provides insight into brain chemistry and nervous system activity.

Nutrition and Oxalates: Analyzes dietary balance and risks such as kidney stones from high oxalate levels.

Who can benefit from the MIP test?2026-08-27T17:33:17+01:00
The test is particularly useful for individuals experiencing unexplained chronic symptoms, neurological issues, fatigue, gut dysfunction, or anyone looking for personalized insights into their biochemical health.
What methodology is used for KBMO’s MIP?2026-08-27T17:33:39+01:00
We use a triple-quad LC/MS/MS instrument to analyze our samples.
What makes the MIP better than other Organic Acids Tests in the market?2026-08-27T17:34:30+01:00
Please see “Why the MIP” video on the MIP product page.
Does KBMO offer resources to help interpret the MIP’s results2026-08-27T17:35:02+01:00
KBMO offers free consults to practitioners that run the test. Please contact us to receive the link to schedule a consult.
How often do you recommend patients to perform the MIP?2026-08-27T17:35:23+01:00
Practitioners will run the MIP every three months for patients currently going through treatment.  Patients that are undergoing wellness checks typically run the MIP every 6-12 months.
Do I Need to Stop Taking Any of My Medications Before I Collect My Sample?2026-08-27T17:35:47+01:00
No.
Who Can Order Testing?2026-08-27T17:36:19+01:00
Any licensed practitioner.
Is KBMO Accredited or Certified?2026-08-27T17:36:43+01:00
Yes.  KBMO is a CLIA accredited laboratory.
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